I don't run E-85, but if you were going to do it and make it worth while, you'd need a retune of your fuel and ignition maps. The ideal AF ratio for e-85 is different from gasoline and since the equivalent octane is much higher you can get away with much more aggresive timing to get a little bit of power/efficiency out of it.
I don't know if the alcohol has any impact on things like fuel lines, seals, gaskets, etc though.
I don't know specifically about the escort components, but I know some engines have trouble even with the 10% ethanol gas that's common across the country now. Small engines especially have problems with o-rings and seals and whatnot getting eaten up.
In order to run e-85 you'd most likely need to go full standalone engine management, because you're going to need a different A/F ratio as well as advanced timing to get decent performance. Even then, some folks experience 20-30% reduction in fuel economy when using a car designed for e-85.